Background

Currently, CPython’s internal bytecode format stores instructions with no args as 1 byte, instructions with small args as 3 bytes, and instructions with large args as 6 bytes (actually, a 3-byte EXTENDED_ARG followed by a 3-byte real instruction). While bytecode is implementation-specific, many other implementations (PyPy, MicroPython, …) use CPython’s bytecode format, or variations on it.

Python exposes as much of this as possible to user code. For example, you can write a decorator that takes a function’s __code__ member, access its co_code bytecode string and other attributes, build a different code object, and replace the function’s __code__.
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If you want to skip all the tl;dr and cut to the chase, jump to Concrete Proposal.

Why can’t we write list.len()? Dunder methods C++ Python Locals What raises on failure? Method objects What about set and delete? Data members Namespaces Bytecode details Lookup overrides Introspection C API Concrete proposal CPython Analysis

Why can’t we write list.len()?

Python is an OO language. To reverse a list, you call lst.reverse(); to search a list for an element, you call lst.index().
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Many people, when they first discover the heapq module, have two questions:

Why does it define a bunch of functions instead of a container type? Why don't those functions take a key or reverse parameter, like all the other sorting-related stuff in Python? Why not a type?

At the abstract level, it's often easier to think of heaps as an algorithm rather than a data structure.
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Currently, in CPython, if you want to process bytecode, either in C or in Python, it’s pretty complicated.

The built-in peephole optimizer has to do extra work fixing up jump targets and the line-number table, and just punts on many cases because they’re too hard to deal with. PEP 511 proposes a mechanism for registering third-party (or possibly stdlib) optimizers, and they’ll all have to do the same kind of work.
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One common "advanced question" on places like StackOverflow and python-list is "how do I dynamically create a function/method/class/whatever"? The standard answer is: first, some caveats about why you probably don't want to do that, and then an explanation of the various ways to do it when you really do need to.

But really, creating functions, methods, classes, etc. in Python is always already dynamic.

Some cases of "I need a dynamic function" are just "Yeah? And you've already got one".
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A few years ago, Cesare di Mauro created a project called WPython, a fork of CPython 2.6.4 that “brings many optimizations and refactorings”. The starting point of the project was replacing the bytecode with “wordcode”. However, there were a number of other changes on top of it.

I believe it’s possible that replacing the bytecode with wordcode would be useful on its own.
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